izinyathelo ezinemininingwane mayelana nendlela yokusebenzisa i-embolic microspheres

Ama-Embolic Microspheres ama-microsphere e-hydrogel acindezelayo anomumo ojwayelekile, indawo ebushelelezi, nosayizi olinganisiwe, akhiwa ngenxa yokuguqulwa kwamakhemikhali ezintweni ze-polyvinyl alcohol (PVA). I-Embolic Microspheres iqukethe i-macromer ethathwe ku-polyvinyl alcohol (PVA), futhi ayi-hydrophilic, ayi-resorbable, futhi atholakala ngebanga losayizi. Isixazululo sokulondoloza yisisombululo se-sodium chloride esingu-0.9%. Okuqukethwe kwamanzi e-microsphere eyenziwe nge-polymerized ngokugcwele kungama-91% ~ 94%. Ama-Microsphere angakwazi ukubekezelela ukucindezelwa okungama-30%.

I-Embolic Microspheres ihloselwe ukusetshenziselwa ukuhlanganisa i-arteriovenous malformations (AVMs) kanye nezimila ze-hypervascular, kuhlanganise ne-uterine fibroids. Ngokuvimbela ukunikezwa kwegazi endaweni okuhlosiwe, isimila noma ukukhubazeka kulambile ngenxa yezakhi zomzimba futhi ziyancipha ngosayizi.

Kulesi sihloko, sizokukhombisa izinyathelo ezinemininingwane mayelana nendlela yokusebenzisa i-Embolic Microspheres.

Ukulungiswa kwezimpahla

Kudingeka ukuthi kulungiswe isirinji engu-1 20ml, 2 10ml isirinji, 3 1ml noma 2ml amasirinji, izindlela ezintathu, isikelo sokuhlinzwa, inkomishi eyinyumba, izidakamizwa ze-chemotherapy, ama-embolic microspheres, imidiya ehlukile, namanzi omjovo.

Isinyathelo 1: Lungiselela izidakamizwa ze-chemotherapy

Sebenzisa isikelo sokuhlinza ukuze ukhulule ibhodlela lomuthi we-chemotherapeutic bese uthela umuthi we-chemotherapeutic enkomishini eyinyumba.
Uhlobo nomthamo wezidakamizwa ze-chemotherapeutic kuncike ezidingweni zomtholampilo.

Sebenzisa amanzi ngomjovo ukuze uhlakaze izidakamizwa ze-chemotherapy, futhi ukugxila okunconywayo kungaphezu kuka-20mg/ml.

Angemva kokuba isidakamizwa se-chemotherapeutic sesihlakazwe ngokugcwele, isixazululo somuthi we-chemotherapeutic sakhishwa ngesirinji engu-10ml.

Isinyathelo sesi-2: Ukukhishwa kwama-embolic microspheres aphethe izidakamizwa

Ama-microspheres afakwe embolized anyakaziswa ngokuphelele, afakwa enalithini yesirinji ukulinganisa ingcindezi ebhodleleni,bese ukhipha ikhambi nama-microspheres ebhodleleni le-cillin ngesirinji engu-20ml.

Vumela isirinji ime imizuzu engu-2-3, futhi ngemva kokuba ama-microspheres ehlezi, i-supernatant ixoshwa ngaphandle kwesisombululo.

Isinyathelo sesi-3: Layisha izidakamizwa ze-Chemotherapeutic ku-Embolic Microspheres

Sebenzisa izindlela ezi-3 ze-stopcock ukuxhuma isirinji ne-embolic microsphere kanye nesirinji ngomuthi we-chemotherapy, qaphela ukuxhumana ngokuqinile kanye nesiqondiso sokugeleza.
Phusha isirinji yesidakamizwa se-chemotherapy ngesandla esisodwa, bese udonsa isirinji equkethe ama-embolic microspheres ngesinye isandla. Ekugcineni, umuthi we-chemotherapy kanye ne-microsphere kuxutshwa ngesirinji engu-20ml, nyakazisa isirinji kahle, bese uyishiya imizuzu engama-30, uyinyakazise njalo emizuzwini emi-5 phakathi nenkathi.

Isinyathelo sesi-4: Engeza imidiya yokugqama

Ngemuva kokuthi ama-microspheres alayishwe izidakamizwa ze-chemotherapeutic imizuzu engu-30, umthamo wesisombululo ubalwa.
Engeza izikhathi ezingu-1-1.2 ivolumu ye-ejenti yokuqhathanisa phakathi kwe-stopcock yezindlela ezintathu, unyakazise kahle futhi uyeke ume imizuzu emi-5.

Isinyathelo sesi-5: Ama-Microsphere asetshenziswa kunqubo ye-TACE

Nge-three way stopcock, jova cishe u-1ml wama-microsphere kusirinji engu-1ml.

Ama-microspheres ajovwe ku-microcatheter ngomjovo we-pulsed.

Ukunakwa komhlahlandlela:

Sicela uqinisekise ukusebenza kwe-aseptic.
Qinisekisa ukuthi izidakamizwa ze-chemotherapeutic zihlakazwa ngokuphelele ngaphambi kokulayisha izidakamizwa.
Ukuqoqwa kwezidakamizwa ze-chemotherapy kuzothinta umphumela wokulayisha izidakamizwa, ukuphakama okuphezulu, ukusheshisa izinga le-adsorption, ukuhlushwa okunconywayo kokulayisha izidakamizwa akukho ngaphansi kuka-20mg/ml.
Amanzi angenalutho kuphela omjovo noma umjovo we-glucose ongu-5% okufanele asetshenziselwe ukuncibilikisa izidakamizwa ze-chemotherapy.
Izinga lokuncibilika kwe-doxorubicin emanzini angenalutho ukuze umjovo lisheshe kancane kunomjovo we-glucose ongu-5%.
Umjovo we-glucose ongu-5% uncibilikisa i-pirarubicin ngokushesha kancane kunamanzi angenalutho omjovo.
Ukusetshenziswa kwe-ioformol 350 njengendlela yokuqhathanisa bekukulungele kakhulu ukumiswa kwama-microspheres.
Uma ujova esimila nge-microcatheter, kusetshenziswa umjovo we-pulse, okulungele kakhulu ukumiswa kwe-microsphere.