Kuyini ama-Embolic Microspheres?

Izinkomba Zokusebenzisa (Chaza)

Ama-Microsphere e-Emboliczenzelwe ukusetshenziselwa ukuvimbela ukukhubazeka kwemithambo yegazi (ama-AVM) kanye nezimila zemithambo yegazi, okuhlanganisa ne-uterine fibroids.

 

Igama Elivamile noma Elijwayelekile: Ukuhlukaniswa Kwe-Polyvinyl Alcohol Embolic Microspheres

Igama: Idivayisi Yokumbolisa Imithambo Yemithambo

Ukuhlukaniswa: Isigaba II

Iphaneli: Inhliziyo Nemithambo Yegazi

 

Incazelo Yedivayisi

 

Ama-Embolic Microspheres angama-microspheres e-hydrogel acindezelwayo anesimo esijwayelekile, ubuso obubushelelezi, kanye nosayizi olinganisiwe, akhiwa ngenxa yokuguqulwa kwamakhemikhali ezintweni ze-polyvinyl alcohol (PVA). Ama-Embolic Microspheres aqukethe i-macromer etholakala ku-polyvinyl alcohol (PVA), futhi ayathandeka emanzini, awakwazi ukusongelwa, futhi atholakala ngobukhulu obuhlukahlukene. Isixazululo sokugcina siyisisombululo se-sodium chloride esingu-0.9%. Okuqukethwe kwamanzi kwe-microsphere egcwele i-polymer kungu-91% ~ 94%. Ama-Microspheres angabekezelela ukucindezelwa okungu-30%.

Ama-Embolic Microspheres anikezwa ahlanzekile futhi apakishwe emabhodleleni engilazi avaliwe.

Ama-Embolic Microspheres ahloselwe ukusetshenziselwa ukuvimbela ukukhubazeka kwemithambo yegazi (ama-AVM) kanye nezimila ezithwala igazi eliningi, okuhlanganisa ne-uterine fibroids. Ngokuvimba ukuphakelwa kwegazi endaweni okuqondiwe kuyo, isimila noma ukukhubazeka kuyaphela izakhamzimba futhi kunciphe ngobukhulu.

Ama-Embolic Microspheres angalethwa ngama-microcatheters ajwayelekile kububanzi be-1.7-4 Fr. Ngesikhathi sokusetshenziswa, ama-Embolic Microspheres axutshwa ne-ejenti yokungafani engeyona i-ionic ukuze kwakheke isixazululo sokumiswa. Ama-Embolic Microspheres enzelwe ukusetshenziswa kanye futhi anikezwa ahlanzekile futhi angenawo ama-pyrogenic. Ukucushwa kwedivayisi ye-Embolic Microsphere kuchazwe kuThebula 1 kanye neThebula 2 ngezansi.

Phakathi kwezinhlobo ezahlukene zobukhulu be-Embolic Microspheres, izinhlobo zobukhulu ezingasetshenziswa ekufakweni kwe-uterine fibroid yi-500-700μm, 700-900μm kanye ne-900-1200μm.

Ithebula: Ukucushwa kwedivayisi ye-Embolic Microspheres
Umkhiqizo Ikhodi	Kulinganisiwe Usayizi (µm)	Ubuningi	Isibonakaliso
			Izimila Ezine-Hypervascular/ I-Arteriovenous Ukukhubazeka	I-Fibroid Yesibeletho
B107S103	100-300	Ama-microspheres angu-1ml: 7ml 0.9% i-sodium chloride	Yebo	No
B107S305	300-500	Ama-microspheres angu-1ml: 7ml 0.9% i-sodium chloride	Yebo	No
B107S507	500-700	Ama-microspheres angu-1ml: 7ml 0.9% i-sodium chloride	Yebo	Yebo
B107S709	700-900	Ama-microspheres angu-1ml: 7ml 0.9% i-sodium chloride	Yebo	Yebo
B107S912	900-1200	Ama-microspheres angu-1ml: 7ml 0.9% i-sodium chloride	Yebo	Yebo
B207S103	100-300	Ama-microspheres angu-2ml: 7ml 0.9% i-sodium chloride	Yebo	No
B207S305	300-500	Ama-microspheres angu-2ml: 7ml 0.9% i-sodium chloride	Yebo	No
B207S507	500-700	Ama-microspheres angu-2ml: 7ml 0.9% i-sodium chloride	Yebo	Yebo
B207S709	700-900	Ama-microspheres angu-2ml: 7ml 0.9% i-sodium chloride	Yebo	Yebo
B207S912	900-1200	Ama-microspheres angu-2ml: 7ml 0.9% i-sodium chloride	Yebo	Yebo

 

Umkhiqizo Ikhodi	Kulinganisiwe Usayizi (µm)	Ubuningi	Isibonakaliso
			Izimila Ezine-Hypervascular/ I-Arteriovenous Ukukhubazeka	I-Fibroid Yesibeletho
U107S103	100-300	Ama-microspheres angu-1ml: 7ml 0.9% i-sodium chloride	Yebo	No
U107S305	300-500	Ama-microspheres angu-1ml: 7ml 0.9% i-sodium chloride	Yebo	No
U107S507	500-700	Ama-microspheres angu-1ml: 7ml 0.9% i-sodium chloride	Yebo	Yebo
U107S709	700-900	Ama-microspheres angu-1ml: 7ml 0.9% i-sodium chloride	Yebo	Yebo
U107S912	900-1200	Ama-microspheres angu-1ml: 7ml 0.9% i-sodium chloride	Yebo	Yebo
U207S103	100-300	Ama-microspheres angu-2ml: 7ml 0.9% i-sodium chloride	Yebo	No
U207S305	300-500	Ama-microspheres angu-2ml: 7ml 0.9% i-sodium chloride	Yebo	No
U207S507	500-700	Ama-microspheres angu-2ml: 7ml 0.9% i-sodium chloride	Yebo	Yebo
U207S709	700-900	Ama-microspheres angu-2ml: 7ml 0.9% i-sodium chloride	Yebo	Yebo
U207S912	900-1200	Ama-microspheres angu-2ml: 7ml 0.9% i-sodium chloride	Yebo	Yebo